https://doi.org/10.36106/paripex/8501801
Journal: PARIPEX INDIAN JOURNAL OF RESEARCH, 2022, p.45-47
Publisher: World Wide Journals
Authors: Sandeep Chandrakar, Rajendra Ratre, Nitish Kumar Rai, T Narasimha Murty
Abstract
INTRODUCTION : H. pylori is a gastric pathogen that colonizes approximately 50%-60% of the world's population. Infection with H. pylori causes chronic inflammation and significantly increases the risk of developing duodenal, gastric ulcer disease and gastric carcinoma. This study is undertaken to determine the clinical and pathological profile of gastric carcinoma in our institute and to find out the prevalence of H. pylori infection in gastric carcinoma patients. MATERIALS AND METHODS :We conducted our study in the Department of Surgery, Dr. B. R. A. M. Hospital, Raipur, C.G. over a period of 18 months. It was a hospital based, cross-sectional observational study. During upper GI endoscopy, site of the lesion and macroscopic type of the lesions were identified and recorded. Multiple tissue biopsy samples (>10) were collected from non-necrosed region of cancer. One piece of each paired specimen were immediately subjected to RapidUrease Test dry kit (RUT) for detection of Helicobacter pylori. Further these biopsy specimens were subjected to modified giemsa staining and culture. RESULTS : Out of the 70 cases of gastric carcinoma, the prevalence of H.pylori was 64.28% . The most common age group associated with gastric carcinoma with H.pylori infection was more than 60 years. There was male predominance seen for both gastric carcinoma and gastric carcinoma positive for H.pylori infection. The most common lesion for gastric carcinoma and those positive for H.pylori was ulceroproliferative type. The most common site of stomach involved in cases of Gastric carcinoma associated with H.pylori infection was antrum+pylorus of stomach. The most common histological type of gastric carcinoma associated with H.pylori infection was poorly differentiated adenocarcinoma CONCLUSION : On the basis of our study it is evident that H.pylori is an independent risk factor for gastric carcinoma. .Infection with H. pylori causes chronic inflammation and significantly increases the risk of developing duodenal, gastric ulcer disease and gastric carcinoma.
List of references
- Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International journal of cancer. 2010 Dec 15;127(12):2893-917..
https://doi.org/10.1002/ijc.25516 - Kalyani R, Das S, Kumar M. ―Pattern of cancer in adolescent and young adults--a ten year study in India.‖ Asian Pac J Cancer Prev 11(2010):655-9.
- Schistosomes , liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum. 1994;61:1–241. [PubMed] [Google Scholar]
https://doi.org/10.1002/ijc.2910600502 - Deen NS, Huang SJ, Gong L, Kwok T, Devenish RJ. The impact of autophagic processes on the intracellular fate of Helicobacter pylori: more tricks from an enigmatic pathogen? Autophagy. 2013;9:639–652. [PMC free article] [PubMed] [Google Scholar]
https://doi.org/10.4161/auto.23782 - Talukder SG. Association of Helicobacter pylori with gastric cancer and other gastroduodenal lesions (Thesis). Dhaka: University of Dhaka, 1995.
- Kabir MA, Barua R, Masud H, Ahmed DS, Islam MM, Karim E, Sarker MN, Barman RC. Clinical presentation, histological findings and prevalence of Helicobacter pylori in patients of gastric carcinoma. Faridpur Medical College Journal. 2011;6(2):78-81.
https://doi.org/10.3329/fmcj.v6i2.9205 - Misra V, Misra SP, Singh MK, Singh PA, Dwivedi M. Prevalence of H. pylori in patients with gastric cancer. Indian J Pathol Microbiol. 2007;50:702– 707. [PubMed] [Google Scholar
- Javan NG, Sharon W. Association of Helicobacter pylori infection and stomach cancer: our experience. International Surgery Journal. 2018 Jul 24;5(8):2794-8.
https://doi.org/10.18203/2349-2902.isj20183193 - Hansson LE, Engstrand L, Nyrén O, Lindgren A. Prevalence of Helicobacter pylori infection in subtypes of gastric cancer. Gastroenterology. 1995 Sep 1;109(3):885-8
https://doi.org/10.1016/0016-5085(95)90398-4 - Yamagata H, Kiyohara Y, Aoyagi K, Kato I, Iwamoto H, Nakayama K, Shimizu H, Tanizaki Y, Arima H, Shinohara N, Kondo H. Impact of Helicobacter pylori infection on gastric cancer incidence in a general Japanese population: the Hisayama study. Archives of internal medicine. 2000 Jul 10;160(13):1962-8.
https://doi.org/10.1001/archinte.160.13.1962 - Vishal G Shelat, Juin Fong Thong, Melanie Seah, et al. Role of staging laparoscopy in gastric malignancies - our institutional experience. World J Gastrointest Surg. 2012; 4: 214-219.
https://doi.org/10.4240/wjgs.v4.i9.214 - Ashis Kumar Saha, Somnath Maitra, Subhas Chandra Hazra. Epidemiology of gastric cancer in the Gangetic areas of West Bengal. ISRN Gastroenterol. 2013;2013:823483
https://doi.org/10.1155/2013/823483 - Chrungoo RK, Mala TA, Gupta R, et al. Role of laparoscopic surgery in cancer of stomach:Our early experience. Int J Cancer Ther Oncol. 2015; 3:3320.
https://doi.org/10.14319/ijcto.33.20 - Abbas Z, Khan HA, Awan S, Ahmad Z. Distribution of gastric carcinoma in an area with a high prevalence of Helicobacter pylori. The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology.. 2017;28(2):98.
https://doi.org/10.5152/tjg.2017.17607 - Qurieshi MA, Masoodi MA, Kadla SA, et al. Gastric cancer in Kashmir. Asian Pac J Cancer Prev. 2011;12:303-307.
- Hire P, Golhar KB. Role of Staging Laparoscopy in Gastric Carcinoma. International Journal of Advance Research, Ideas and Innovations in Technology. 2017;3:204-214.
- Kato M, Asaka M, Shimizu Y, Nobuta A, Takeda H, Sugiyama T, Members of the Multi‐Centre Study Group. Relationship between Helicobacter pylori infection and the prevalence, site and histological type of gastric cancer. Alimentary pharmacology & therapeutics. 2004 Jul;20:85-9
https://doi.org/10.1111/j.1365-2036.2004.01987.x - Wang X, Wei M, Sun Z. An association study of histological types of gastric carcinoma with Helicobacter pylori infection. Cell biochemistry and biophysics. 2014 Nov 1;70(2):1283-7.
https://doi.org/10.1007/s12013-014-0052-z
About this publication
Number of citations | 0 |
Number of works in the list of references | 18 |
Journal indexed in Scopus | No |
Journal indexed in Web of Science | No |